个人简介：
李宏宝，副教授，硕
/
博士生导师。
主要研究方向为：宿主肠道微生物与心血管疾病、慢性肾脏病。
2017-2018
年在美国佛罗里达大学
Mohan K Raizada
教授实验室公派访学。目前主持国家自然科学基金
2
项、中国博士后面上项目
2
项、陕西省重点研发项目
1
项、陕西省博士后基金
1
项、陕西省自然科学基金青年项目
1
项，教育部春晖计划项目
1
项，另参与国家自然科学基金重大研究计划项目、面上项目等多个科研项目。累计发表
SCI
论文
45
篇，其中以第一作者
/
通讯作者在
Circulation Research, Hypertension, Gut Microbes
等国际学术期刊上发表
SCI
收录论文
16
篇。其中影响因子大于
10
的高水平
SCI
论文
3
篇。
目前
任陕西省生理科学会理事。陕西省健康促进与教育协会血液净化专业委员会副主任委员。
任
SCI
杂志
Frontiers in Nutrition
(IF=6.57
；副主编
)
，
Nutrients
(IF=6.706
；客座副主编
)
，
Frontiers in Cellular and Infection Microbiology
(IF=6.073
；副主编
)
，
Cardiovascular Toxicology
(IF=3.23)
编委，中华高血压杂志青年编委等
。获陕西省高等学校科学技术二等奖
1
项。
研究领域（方向）：
1.
宿主肠道微生物与心血管疾病、慢性肾脏病；
2.
宿主肠道微生物与肺动脉高压。
教育与工作经历：
2012
年获兰州大学生理学硕士学位。
2015
年毕业于西安交通大学医学院，获博士学位，并留校工作。
2017-2018
年在美国佛罗里达大学公派访学。
2019/03-
至今，西安交通大学，副教授
/
博导。
国际合作与交流情况：
目前主要与美国佛罗里达大学
Mohan K Raizada
教授，美国托莱多大学的
Bina Joe
教授和杨涛助理教授合作。
主持科研项目情况：
国家自然科学基金面上项目，
2022-01
至
2025-12
，在研，主持
国家自然科学基金青年项目，
2018-01
至
2020-12,
已结题，主持
西安交通大学基本科研业务费，
2020-01
至
2022
年
-12
，在研，主持
陕西省重点研发一般项目，
2021-01
至
2022-12
，在研，主持
中国博士后面上项目一等资助，
2020-01
至
2021-12,
在研，主持
6.
教育部“春晖计划”合作科研项目，
2020-01
至
2021-12,
在研，主持
7.
陕西省自然科学基金青年项目，
2017-01
至
2018-12
，已结题，主持
8.
中国博士后面上项目二等资助，
2017-01
至
2018-12
，已结题，主持
9.
陕西省博士后基金项目，
2016-01
至
2017-12
月，已结题，主持
近五年发表部分论文情况：本人通讯作者以
*
标出
Hong-Bao Li*
(
通讯作者
)
, Meng-Lu Xu, Xu-Dong Xu, Yu-Yan Tang, Hong-Li Jiang, Lu Li, Wen-Jie Xia, Nan Cui, Juan Bai, Zhi-Ming Dai, Bei Han, Ying Li, Bo Peng, Yuan-Yuan Dong, Sachin Aryal, Ishan Manandhar, Mahmoud Ali Eladawi, Rammohan Shukla, Yu-Ming Kang*, Bina Joe*, Tao Yang*,
Faecalibacterium prausnitzii
attenuates CKD via butyrate-renal GPR43 axis
，
Circulation Research
，
2022,131(9):e120-e134. IF: 23.213 (
封面论文
).
Meng-Lu Xu, Bo Peng, Juan Bai, Lu Li, Yan Du, Zhi-Qiang Wang, Sha-Sha Li, Xiao-Xi Liu, Yuan-Yuan Dong, Jun-Zhe Wu, Ling-Xiao Xiong, Lei Chen, Hong-Bao Li*
(
通讯作者
)
, Hong-Li Jiang*, Diosgenin exerts an antihypertensive effect in spontaneously hypertensive rats via gut-brain communication,
Food & Function
, 2022, 13(18):9532-9543. IF: 6.317.
Lin Song, Jiaqi Cui, Shuyuan Hu, Rui Wang, Hong-Bao Li*
(
通讯作者
)
, Bo Sun*,
Maternal treatment with metformin persistently ameliorates high-Fat diet-induced metabolic symptoms and modulates gut microbiota in rat offspring,
Nutrients
, 2022, 14(17):3612. IF: 6.706.
Wen-Jie Xia, Meng-Lu Xu, Xiao-Jing Yu, Meng-Meng Du, Xu-Hui Li, Tao Yang, Lu Li, Qing Su, Jia-Xi Xu, Xiao-Lian Shi,
Hong-Bao Li*(
通讯作者
)
, Yu-Ming Kang, Antihypertensive effects of exercise involve reshaping of gut microbiota and improvement of gut-brain axis in spontaneously hypertensive rat,
Gut Microbes,
2021, 13(1):1-24. IF: 10.245.
Hong-Bao Li
, Meng-Lu Xu, Meng-Meng Du, Xiao-Jing Yu, Juan Bai, Wen-Jie Xia, Zhi-Ming Dai, Chang-Xing Li, Ying Li , Qing Su, Xiao-Min Wang, Yuan-Yuan Dong, Yu-Ming Kang
，
Curcumin ameliorates hypertension via gut-brain communication in spontaneously hypertensive rat,
Toxicology and Applied Pharmacology
, 2021, 429:115701.
Ying Li, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia,
Hong-Bao Li
*
(
通讯作者
)
, Yu-Ming Kang*, Altered gut microbiota is involved in the anti-hypertensive effects of Vitamin C in spontaneously hypertensive rat,
Molecular Nutrition and Food Research
, 2021, 65(7):e2000885. IF: 6.575 (
封面论文
)
Ying Li*, Salman Zafar, Rawya Mohamed Salih Ibrahim, Hong-Li Chi, Tong Xiao, Wen-Jie Xia,
Hong-Bao Li
*
(
通讯作者
)
, Yu-Ming Kang*, Exercise and food supplement of vitamin C ameliorate hypertension through improvement of gut microflora in the spontaneously hypertensive rats,
Life Sciences
, 2021, 269:119097. IF: 6.780.
Hong-Bao Li,
Tao Yang
，
Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Maternal treatment with captopril persistently alters gut-brain communication and attenuates hypertension of male Offspring
，
Hyperte
nsion, 2020, 75:1315-1324. IF: 10.19.
Hong-Bao Li
, Xiao-Jing Yu, Juan Bai, Qing Su, Mo-Lin Wang, Chan-Juan Huo, Wen-Jie Xia, Qiu-Yue Yi, Kai-Li Liu, Li-Yan Fu, Guo-Qing Zhu, Jie Qi, Yu-Ming Kang, Silencing salusin β ameliorates heart failure in aged spontaneously hypertensive rats by ROS-relative MAPK/NF-κB pathways in the paraventricular nucleus,
International Journal of Cardiology
, 2019, 280:142-151.
Hui Zhang,
Hong-Bao Li (
共同一作
)
, Jian-Rui Lyu, Xiao-Ming Lei, Wei Li, Gang Wu, Jun Lyu, Zhi-Ming Dai, Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection,
International Journal of Infectious Diseases
, 2020, 96:19-24.
Meng-Lu Xu, Xiao-Jing Yu, Jian-Qiang Zhao, Yan Du, Wen-Jie Xia, Qing Su, Meng-Meng Du, Qing Yang, Jie Qi, Ying Li, Shao-Wen Zhou, Guo-Qing Zhu,
Hong-Bao Li
*(
通讯作者
), Yu-Ming Kang. Calcitriol ameliorated autonomic dysfunction and hypertension by down-regulating inflammation and oxidative stress in the paraventricular nucleus of SHR.
Toxicology and Applied Pharmacology
, 2020, 394:114950.
Tao Yang,
Hong-Bao Li,
Aline C Oliveira, Ruby Goel
，
Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada,Transcriptomic signature of gut microbiome-contacting cells in colon of spontaneously hypertensive rats
，
Physiological Genomics
，
2020, 2(3):121-132.
Tao Yang, Victor Aquino, Gilberto O. Lobaton,
Hong-Bao Li,
Luis Colon-Perez, Ruby Goel, Yan-Fei Qi, Jasenka Zubcevic, Marcelo Febo, Elaine M. Richards, Carl J. Pepine, Mohan K. Raizada, Sustained captopril-Induced reduction in blood pressure is associated with alterations in gut-brain axis in the spontaneously hypertensive rat,
Journal of the American Heart Association
, 2019, 8(4):e010721. IF: 4.605.
Xiao-Jing Yu, Yu-Wang Miao,
Hong-Bao Li (
共同一作
)
, Qing Su, Kai-Li Liu, Li-Yan Fu, Yi-Kang Hou, Xiao-Lian Shi, Ying Li, Jian-Jun Mu, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Philip J Ebenezer, Joseph Francis, Yu-Ming Kang, Blockade of Endogenous Angiotensin-(1-7) in Hypothalamic Paraventricular Nucleus Attenuates High Salt-Induced Sympathoexcitation and Hypertension,
Neuroscience Bulletin
, 2019, 35(1):47-56.
Hong-Bao Li
, Chan-Juan Huo, Qing Su, Xiang Li, Juan Bai, Guo-Qing Zhu, Yu-Ming Kang, Exercise training attenuates proinflammatory cytokines, oxidative stress and modulates neurotransmitters in the rostral ventrolateral medulla of salt-induced hypertensive rats,
Cellular Physiology and Biochemistry
, 2018;48(3):1369-1381.
Hong-Bao Li
, Xiang Li, Chan-Juan Huo, Qing Su, Jing Guo, Zu-Yi Yuan, Guo-Qing Zhu, Xiao-Lian Shi, Jin-Jun Liu, Yu-Ming Kang, TLR4/MyD88/NF-κB signaling and PPAR-γ within the paraventricular nucleus are involved in the effects of telmisartan in hypertension,
Toxicology and Applied Pharmacology
, 2016, 305:93-102.
Qiu-Yue Yi,
Hong-Bao Li (
共同一作
),
Jie Qi, Xiao-Jing Yu, Chan-Juan Huo, Xiang Li, Juan Bai, Hong-Li Gao, Bo Kou, Kai-Li Liu, Dong-Dong Zhang, Wen-Sheng Chen, Wei Cui, Guo-Qing Zhu, Xiao-Lian Shi, Yu-Ming Kang,
Toxicology letters
, 2016, 262:105-113.
Hong-Bao Li
, Da-Nian Qin, Kang Cheng, Qing Su, Yu-Wang Miao, Jing Guo, Meng Zhang, Guo-Qing Zhu, Yu-Ming Kang, Central blockade of salusin β attenuates hypertension and hypothalamic inflammation in spontaneously hypertensive rats,
Scientific Reports
, 2015, 5:11162.
Hong-Bao Li
, Da-Nian Qin, Yu-Ping Suo, Jing Guo, Qing Su, Yu-Wang Miao, Wen-Yan Sun, Qiu-Yue Yi, Wei Cui, Kang Cheng, Guo-Qing Zhu, Yu-Ming Kang, Blockade of salusin β in hypothalamic paraventricular nucleus attenuates hypertension and cardiac hypertrophy in salt-induced hypertensive rats,
Journal of cardiovascular pharmacolog
y, 2015, 66(4):323-331.
Hong-Bao Li
, Yan Lu, Jin-Jun Liu, Yu-Wang Miao, Tian-Zhen Zheng, Qing Su, Jie Qi, Hong Tan, Zu-Yi Yuan, Guo-Qing Zhu, Yu-Ming Kang, Salusin β within the nucleus tractus solitarii suppresses blood pressure via inhibiting the activities of presympathetic neurons in the rostral ventrolateral medulla in spontaneously hypertensive rats,
Cardiovascular Toxicolog
y, 2016, 16(3):223-234.
Hong-Bao Li
, Da-Nian Qin, Le Ma, Yu-Wang Miao, Dong-Mei Zhang, Yan Lu, Xin-Ai Song, Guo-Qing Zhu, Yu-Ming Kang, Chronic infusion of lisinopril into hypothalamic paraventricular nucleus modulates cytokines and attenuates oxidative stress in rostral ventrolateral medulla in hypertension,
Toxicology and Applied Pharmacology
, 2014, 279(2):141-149.
联系方式：
电子邮箱：
hongbaoli1985@163.com
or
lhb15891752503@mail.xjtu.edu.cn
个人主页：
http://gr.xjtu.edu.cn/web/lhb15891752503
联系地址：西安市雁塔西路
76
号西安交通大学医学部
