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Code  ›  都是肿瘤模型,凭什么说肿瘤类器官是“试药替身”? | MCE
cell 生物技术
https://www.medchemexpress.cn/literature/mce-research-learning-organoid.html
迷茫的鸵鸟
1 年前
  • Anti-infection 抗感染
  • ADC Related 抗体偶联药物相关
  • Apoptosis 凋亡
  • Autophagy 自噬
  • Cell Cycle/DNA Damage 细胞周期/DNA 损伤
  • Cytoskeleton 细胞骨架
  • Epigenetics 表观遗传学
  • GPCR/G Protein G 蛋白偶联受体/G 蛋白
  • Immunology/Inflammation 免疫及炎症
  • JAK/STAT Signaling JAK/STAT 信号通路
  • MAPK/ERK Pathway MAPK/ERK 信号通路
  • Membrane Transporter/Ion Channel 跨膜转运
  • Metabolic Enzyme/Protease 代谢酶/蛋白酶
  • Neuronal Signaling 神经信号通路
  • NF-κB NF-κB 信号通路
  • PI3K/Akt/mTOR PI3K/Akt/mTOR 信号通路
  • PROTAC 蛋白降解靶向嵌合体
  • Protein Tyrosine Kinase/RTK 蛋白酪氨酸激酶
  • Stem Cell/Wnt 干细胞及 Wnt 通路
  • TGF-beta/Smad TGF-beta/Smad 信号通路
  • Vitamin D Related/Nuclear Receptor 维生素 D 相关/核受体
  • Others 其他
Anti-infection
  • Antibiotic
  • Arenavirus
  • Bacterial
  • CMV
  • EBV
  • Enterovirus
  • Filovirus
  • Flavivirus
  • Fungal
  • HBV
  • HCV
  • HCV Protease
  • HIV
  • HIV Protease
  • HPV
  • HSV
  • Influenza Virus
  • Orthopoxvirus
  • Parasite
  • RABV
  • Reverse Transcriptase
  • RSV
  • More...
Antibody-drug Conjugate/ADC Related
  • ADC Antibody
  • ADC Cytotoxin
  • ADC Linker
  • Antibody-Drug Conjugates (ADCs)
  • Drug-Linker Conjugates for ADC
  • PROTAC-Linker Conjugates for PAC
Apoptosis
  • Apoptosis
  • Bcl-2 Family
  • c-Myc
  • Caspase
  • DAPK
  • Ferroptosis
  • FKBP
  • IAP
  • MDM-2/p53
  • Necroptosis
  • PKD
  • Pyroptosis
  • RIP kinase
  • Survivin
  • Thymidylate Synthase
  • TNF Receptor
Autophagy
  • Atg4
  • Autophagy
  • Beclin1
  • FKBP
  • LRRK2
  • Mitophagy
  • ULK
Cell Cycle/DNA Damage
  • Antifolate
  • APC
  • ATF6
  • ATM/ATR
  • Aurora Kinase
  • Casein Kinase
  • CDK
  • Checkpoint Kinase (Chk)
  • CRISPR/Cas9
  • Cyclin G-associated Kinase (GAK)
  • Deubiquitinase
  • DNA Alkylator/Crosslinker
  • DNA Stain
  • DNA-PK
  • DNA/RNA Synthesis
  • Early 2 Factor (E2F)
  • Eukaryotic Initiation Factor (eIF)
  • G-quadruplex
  • Haspin Kinase
  • HDAC
  • HSP
  • IRE1
  • More...
Cytoskeleton
  • Arp2/3 Complex
  • Dynamin
  • Gap Junction Protein
  • Integrin
  • Kinesin
  • Microtubule/Tubulin
  • Mps1
  • Myosin
  • PAK
  • ROCK
Epigenetics
  • AMPK
  • Aurora Kinase
  • DNA Methyltransferase
  • Epigenetic Reader Domain
  • HDAC
  • Histone Acetyltransferase
  • Histone Demethylase
  • Histone Methyltransferase
  • JAK
  • Methionine Adenosyltransferase (MAT)
  • METTL3
  • MicroRNA
  • PARP
  • PKC
  • Protein Arginine Deiminase
  • Sirtuin
  • Small Interfering RNA (siRNA)
  • TET Protein
GPCR/G Protein
  • 5-HT Receptor
  • Adenylate Cyclase
  • Adrenergic Receptor
  • Amylin Receptor
  • Angiotensin Receptor
  • Apelin Receptor (APJ)
  • Arrestin
  • Bombesin Receptor
  • Bradykinin Receptor
  • Cannabinoid Receptor
  • CaSR
  • CCR
  • CGRP Receptor
  • Cholecystokinin Receptor
  • CRFR
  • CXCR
  • EBI2/GPR183
  • Endothelin Receptor
  • Formyl Peptide Receptor (FPR)
  • Free Fatty Acid Receptor
  • G protein-coupled Bile Acid Receptor 1
  • G Protein-coupled Receptor Kinase (GRK)
  • More...
Immunology/Inflammation
  • AIM2
  • ALCAM/CD166
  • AP-1
  • Arginase
  • Aryl Hydrocarbon Receptor
  • BCL6
  • CCR
  • CD19
  • CD2
  • CD20
  • CD22
  • CD28
  • CD3
  • CD38
  • CD6
  • CD73
  • Complement System
  • COX
  • CTLA-4
  • CX3CR1
  • CXCR
  • Cyclic GMP-AMP Synthase
  • More...
JAK/STAT Signaling
  • EGFR
  • JAK
  • Pim
  • STAT
MAPK/ERK Pathway
  • ERK
  • JNK
  • KLF
  • MAP3K
  • MAP4K
  • MAPKAPK2 (MK2)
  • MEK
  • Mixed Lineage Kinase
  • MNK
  • p38 MAPK
  • Raf
  • Ribosomal S6 Kinase (RSK)
Membrane Transporter/Ion Channel
  • Apical Sodium-Dependent Bile Acid Transporter
  • Aquaporin
  • ATP Synthase
  • BCRP
  • Calcium Channel
  • Calmodulin
  • CFTR
  • Chloride Channel
  • CRAC Channel
  • CRM1
  • EAAT
  • FATP
  • Ferroportin
  • GABA Receptor
  • GLUT
  • GlyT
  • HCN Channel
  • iGluR
  • Monoamine Transporter
  • Monocarboxylate Transporter
  • Na+/Ca2+ Exchanger
  • Na+/H+ Exchanger (NHE)
  • More...
Metabolic Enzyme/Protease
  • 11β-HSD
  • 15-PGDH
  • 17β-HSD
  • 5 alpha Reductase
  • Acetolactate Synthase (ALS)
  • Acetyl-CoA Carboxylase
  • Acyltransferase
  • Adiponectin Receptor
  • Aldehyde Dehydrogenase (ALDH)
  • Aldose Reductase
  • Aminoacyl-tRNA Synthetase
  • Aminopeptidase
  • Amylases
  • Angiotensin-converting Enzyme (ACE)
  • Arginase
  • ATGL
  • ATP Citrate Lyase
  • Carbonic Anhydrase
  • Carboxypeptidase
  • Cathepsin
  • Ceramidase
  • CETP
  • More...
Neuronal Signaling
  • 5-HT Receptor
  • AAK1
  • Adrenergic Receptor
  • Amyloid-β
  • Beta-secretase
  • Calcium Channel
  • CaMK
  • Cannabinoid Receptor
  • CGRP Receptor
  • Cholecystokinin Receptor
  • Cholinesterase (ChE)
  • COMT
  • FAAH
  • GABA Receptor
  • Glucosylceramide Synthase (GCS)
  • GlyT
  • GPR119
  • GPR139
  • GPR55
  • Histamine Receptor
  • Huntingtin
  • iGluR
  • More...
NF-κB
  • IKK
  • Keap1-Nrf2
  • MALT1
  • NF-κB
  • RANKL/RANK
  • Reactive Oxygen Species
PI3K/Akt/mTOR
  • Akt
  • AMPK
  • ATM/ATR
  • DNA-PK
  • GSK-3
  • MELK
  • mTOR
  • PDK-1
  • PI3K
  • PI4K
  • PIKfyve
  • PIN1
  • PTEN
PROTAC
  • ATTECs
  • AUTACs
  • E3 Ligase Ligand-Linker Conjugates
  • Ligands for E3 Ligase
  • Ligands for Target Protein for PROTAC
  • LYTACs
  • Molecular Glues
  • PROTAC Linkers
  • PROTAC-Linker Conjugates for PAC
  • PROTACs
  • SNIPERs
  • Target Protein Ligand-Linker Conjugates
Protein Tyrosine Kinase/RTK
  • Ack1
  • Anaplastic lymphoma kinase (ALK)
  • Bcr-Abl
  • BMX Kinase
  • Btk
  • c-Fms
  • c-Kit
  • c-Met/HGFR
  • Discoidin Domain Receptor
  • DYRK
  • EGFR
  • Ephrin Receptor
  • FAK
  • FGFR
  • FLT3
  • IGF-1R
  • Insulin Receptor
  • Itk
  • JAK
  • PDGFR
  • Pyk2
  • RET
  • More...
Stem Cell/Wnt
  • Casein Kinase
  • ERK
  • Gli
  • GSK-3
  • Hedgehog
  • Hippo (MST)
  • JAK
  • Notch
  • Oct3/4
  • PKA
  • Porcupine
  • ROCK
  • sFRP-1
  • Smo
  • STAT
  • TGF-beta/Smad
  • Wnt
  • YAP
  • β-catenin
  • γ-secretase
TGF-beta/Smad
  • PKC
  • ROCK
  • TGF-beta/Smad
  • TGF-β Receptor
Vitamin D Related/Nuclear Receptor
  • Androgen Receptor
  • Estrogen Receptor/ERR
  • Glucocorticoid Receptor
  • LXR
  • Mineralocorticoid Receptor
  • PPAR
  • Progesterone Receptor
  • RAR/RXR
  • REV-ERB
  • ROR
  • Thyroid Hormone Receptor
  • VD/VDR
Others
  • Amino Acid Derivatives
  • Biochemical Assay Reagents
  • Fluorescent Dye
  • Isotope-Labeled Compounds
  • Others
Cytokines and Growth Factors
Immune Checkpoint Proteins
CAR-T related Proteins
CD Antigens
Fc Receptors
Receptor Proteins
Enzymes & Regulators
Complement System
Ubiquitin Related Proteins
Viral Proteins
Biotinylated Proteins
Fluorescent-labeled Proteins
GMP-grade Proteins
Animal-free Recombinant Proteins
重组蛋白定制
定制合成服务
ADC 相关定制服务
PROTAC 相关定制服务
MCE 试剂盒
分子生物学
  • • PCR & qPCR
  • • RT-PCR
  • • 核酸电泳
  • • 载体构建
  • • 核酸提取与纯化
  • • 限制性核酸内切酶
  • • 耗材
蛋白生物学
  • • 蛋白样本制备
  • • 蛋白纯化
  • • 蛋白电泳、WB
细胞生物学
  • • 细胞培养
  • • 细胞分析
  • • 3D 细胞培养
点击化学 (Click Chemistry)
GMP Small Molecules
诱导疾病模型产品
  • Cytokines and Growth Factors 细胞因子和生长因子
  • Immune Checkpoint Proteins 免疫检查点蛋白
  • CAR-T related Proteins CAR-T 相关蛋白
  • CD Antigens CD 抗原
  • Fc Receptors Fc 受体蛋白
  • Receptor Proteins 受体蛋白
  • Enzymes & Regulators 酶和调节子
  • Complement System 补体系统
  • Ubiquitin Related Proteins 泛素相关蛋白
  • Viral Proteins 病毒蛋白
  • Biotinylated Proteins 生物素标记蛋白
  • Fluorescent-labeled Proteins 荧光标记蛋白
  • GMP-grade Proteins GMP 级蛋白
  • Animal-free Recombinant Proteins 无动物成分重组蛋白
  • Others 其他
  • View More
Cytokines and Growth Factors
  • Interleukin & Receptors
  • Interferon & Receptors
  • Chemokine & Receptors
  • TNF Superfamily
  • CSF & Receptors
  • TGF-beta Superfamily
  • PDGFs & PDGFRs
  • VEGF & VEGFR
  • EGF Superfamily
  • FGF Family
  • HGF & Receptors
  • Neurotrophic Factors
  • Ephrin/Eph Family
  • Angiopoietins
  • IGF family
  • Peptide Hormone & Neuropeptides
Immune Checkpoint Proteins
  • Inhibitory Checkpoint Molecules
  • Stimulatory Immune Checkpoint Molecules
  • Butyrophilins
CAR-T related Proteins
  • B Cell Maturation Antigen (BCMA)
  • FLK-1/VEGFR-2
  • B7-H3
  • CD4
  • CD19
  • CD123
  • CD138/Syndecan-1
  • Epithelial Cell Adhesion Molecule (EpCAM)
  • Folate Receptor 1
  • GPC-3
  • Guanylate Cyclase 2C
  • ErbB2/HER2
  • ErbB3/HER3
  • c-Met/HGFR
  • MSLN
  • CA-125
  • ROR1
  • CEACAM-5
  • Natural Killer Group 2, Member D (NKG2D)
  • Prostate Specific Membrane Antigen
  • CRACC/SLAMF7
  • TROP-2
  • Siglec-6
  • Folate Receptor alpha (FR-alpha)
  • CD33
  • CD70
  • CD138/Syndecan-1
  • CD138/Syndecan-1
  • Nectin-4
  • Carbonic Anhydrase 9 (CA IX)
  • EGFR
  • FLK-1/VEGFR-2
  • CD7
  • CD20
  • Siglec-2/CD22
  • CD30
  • CD38
  • MUC-1/CD227
CD Antigens
  • T Cell CD Proteins
  • B Cell CD Proteins
  • NK Cell CD Proteins
  • Macrophage CD Proteins
  • Monocyte CD Proteins
  • Stem Cell CD Proteins
  • Platelet CD Proteins
  • Erythrocyte CD Proteins
  • Dendritic Cell CD Proteins
  • Epithelial cell CD Proteins
  • Endothelial cell CD Proteins
  • Signal Transduction-related CD Proteins
  • Cell Adhesion-related CD Proteins
Fc Receptors
  • Fc-gamma Receptor
  • FcRn
  • Fc-epsilon Receptor
  • Fc alpha/mu Receptor
  • Polymeric Immunoglobulin Receptor
  • FcμR
  • Fc Receptor-like Proteins
  • Immunoglobulin Fc Region
  • Fc alpha RI/CD89
Receptor Proteins
  • Receptor Tyrosine Kinases
  • Receptor Serine/Threonine Kinases
  • Receptor Tyrosine Phosphatase
  • Receptor Guanylyl Cyclase Family
  • Cell Adhesion Molecules (CAMs)
  • G-Protein-Coupled Receptors (GPCRs)
  • Nuclear Receptor Superfamily
  • Pattern Recognition Receptors
  • Notch family
  • Siglec
  • Leukocyte Immunoglobin-like Receptors
  • Killer-Cell Immunoglobulin-like Receptors
Enzymes & Regulators
  • Oxidoreductases (EC 1)
  • Transferases (EC 2)
  • Hydrolases (EC 3)
  • Lyases (EC 4)
  • Isomerases (EC 5)
  • Ligases (EC 6)
  • Translocases (EC 7)
  • Matrix Metalloproteinases
  • ADAMs/ADAMTSs
  • Cathepsin
  • Carboxypeptidase
  • Angiotensin-converting Enzymes
  • Caspase
  • Carbonic Anhydrase
  • Serine/Threonine Kinase Proteins
  • Protein Tyrosine Kinases
  • Phosphatase
  • Topoisomerase
  • Protease Inhibitors
  • Protein Kinase Inhibitor Peptide (PKI)
  • Cyclin-Dependent Kinase Inhibitor Proteins
  • Cystatin Family
Complement System
  • Complement Component 1
  • Complement Component 2
  • Complement Component 3
  • Complement Component 4
  • Complement Component 5
  • Complement Component 6
  • Complement Component 7
  • Complement Component 8
  • Mannose-binding Protein
  • MASP-1
  • MASP-2
  • Complement Regulatory Proteins
  • Complement Receptor
Ubiquitin Related Proteins
  • Ubiquitin/UBLs
  • Ubiquitin Enzymes
  • Deubiquitinase
Viral Proteins
  • SARS-CoV-2 Proteins
  • Zika Virus Proteins
  • RSV Proteins
  • Hepatitis C Virus Proteins
  • Hepatitis B Virus Proteins
  • HIV Proteins
  • HPV Proteins
  • Influenza Viruses Proteins
  • Dengue Virus Proteins
  • Ebola Virus Proteins
  • Bacterial/Fungal Proteins
Biotinylated Proteins
Fluorescent-labeled Proteins
GMP-grade Proteins
Animal-free Recombinant Proteins
Others
  • 分子生物学
  • •
    PCR & qPCR
  • •
    RT-PCR
  • •
    核酸电泳
  • •
    载体构建
  • •
    核酸提取与纯化
  • •
    限制性核酸内切酶
  • •
    耗材
  • 蛋白生物学
  • •
    蛋白样本制备
  • •
    蛋白纯化
  • •
    蛋白电泳、WB
  • 细胞生物学
  • •
    细胞培养
  • •
    细胞分析
  • •
    3D 细胞培养
  • View More
分子生物学
PCR & qPCR
  • PCR
  • 荧光定量 PCR
RT-PCR
  • RNA 酶抑制剂
  • 反转录试剂盒
核酸电泳
  • 核酸胶染料
  • 琼脂糖
  • 上样&电泳缓冲液
  • DNA Marker
载体构建
  • 无缝克隆试剂盒
核酸提取与纯化
  • 基因组提取纯化
  • 质粒提取纯化
限制性核酸内切酶
耗材
蛋白生物学
蛋白样本制备
  • 细胞裂解
  • 洗涤缓冲液
  • 蛋白酶抑制剂 Cocktail
  • 磷酸酶抑制剂 Cocktail
  • 去乙酰化酶抑制剂Cocktail
  • 激酶抑制剂 Cocktail
蛋白纯化
  • 磁力架
  • 磁珠
  • 亲和层析柱
  • 琼脂糖凝胶珠
  • 平衡缓冲液
  • 结合/洗涤缓冲液
蛋白电泳、WB
  • 电泳缓冲液
  • 蛋白 Marker
  • 转膜缓冲液
  • 封闭缓冲液
  • 结合/洗涤缓冲液
  • 化学显色
  • 上样缓冲液
细胞生物学
细胞培养
  • 细胞转染
  • 支原体清除
  • 无菌抗生素溶液
  • 细胞冻存
  • CEPT cocktail
  • 基础培养基
  • 胎牛血清
  • 平衡盐缓冲液
细胞分析
  • 细胞增殖与毒性检测
  • 报告基因检测
  • 细胞骨架检测
  • 细胞凋亡与细胞周期检测
  • 抗荧光淬灭剂
  • 线粒体分离
  • 外泌体提取、纯化与鉴定
3D 细胞培养
  • 基质胶
  • 肿瘤类器官培养基
  • 正常组织类器官培养基
Matrigel ADMEM/F12, 青霉素/链霉素, L-谷氨酸, B27, N2, BSA, EGF, Noggin, R-spondin-1, 胃泌素, FGF10, FGF-basic, Wnt3A, 前列腺素 E2, 烟酰胺 A-83-01
Y27632
SB202190 经典人肝类器官分离培养基 : ADMEM/F12、青霉素/链霉素、谷氨酰胺、HEPES、B27(不含维A)、N2、N-乙酰半胱氨酸、烟酰胺、胃泌素1、EGF、FGF10、HGF、forskolin、R-spondin-1、Wnt3A、Noggin
Tumoroid-specific 分离培养基 :
经典的人肝类器官分离培养基,去除 R-spondin-1, Wnt3A 和 Noggin,添加地塞米松
A-83-01
Y27632 Matrigel ADMEM/F12,青霉素/链霉素,谷氨酰胺,HEPES, B27,N-乙酰半胱氨酸,EGF, R-spondin-1,胃泌素1, Wnt3A, Noggin 和 FGF A-83-01 (reduced growth factor) ADMEM/F12,青霉素/链霉素,谷氨酰胺,HEPES, B27,n-乙酰半胱氨酸,R-spondin-1, FGF7, FGF10,烟酰胺,Noggin, Primoin和 Neuregulin 1 A-83-01
Y27632 Matrige 含有 EGF, FBS, GlutaMAX 和 Primoin 的肝细胞培养基 Y27632 Matrigel
(growth factor reduced) ADMEM,青霉素/链霉素,primocin, GlutaMAX, B27, EGF,N-乙酰半胱氨酸,FGF10,碱性FGF,烟酰胺,睾酮,前列腺素E2, Noggin 和 R-spondin A-83-01
SB202190 Human FGF-2/4/9/10

FGFs 在早期发育中对中胚层诱导、肢体发育、神经诱导和神经发育有重要作用。在成熟组织中,FGFs 对血管生成、角质形成细胞组织和伤口愈合过程至关重要。

例如 FGF-basic (FGF-2)、FGF-10 是常见的类器官培养 Niche 因子,如肝脏类器官、前列腺类器官。

1. Hanxiao Xu,Dechao Jiao,Aiguo Liu,Kongming Wu. Tumor organoids: applications in cancer modeling and potentials in precision medicine. J Hematol Oncol. 2022; 15, 58.

2. Malia Alexandra Foo, Mingliang You, Lingzhi Wang, Boon‑Cher Goh, et al. Clinical translation of patient-derived tumor organoids- bottlenecks and strategies Preclinical tumor models are an important platform for mechanistic research and testing of new drugs.Biomark Res. 2022 Mar 10;10(1):10. 3. Jarno Drost, Hans Clevers.Organoids in cancer research.Nat Rev Cancer. 2018 Jul;18(7):407-418. 4. Bauer L. LeSavage, Sarah C. Heilshorn, et al. Next-generation cancer organoids. Nat Mater. 2022 Feb;21(2):143-159. 5. Zilong Zhou, Lele Cong, Xianling Cong. Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank. Front Oncol. 2021 Dec 30;11:762184. 6. Colin Rae, Francesco Amato, Chiara Braconi. Patient-Derived Organoids as a Model for Cancer Drug Discovery.Int J Mol Sci. 2021 Mar 27;22(7):3483. 7. Georgios Vlachogiannis, Nicola Valeri, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018 Feb 23;359(6378):920-926.

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