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FGFs 在早期发育中对中胚层诱导、肢体发育、神经诱导和神经发育有重要作用。在成熟组织中,FGFs 对血管生成、角质形成细胞组织和伤口愈合过程至关重要。
例如 FGF-basic (FGF-2)、FGF-10 是常见的类器官培养 Niche 因子,如肝脏类器官、前列腺类器官。
1. Hanxiao Xu,Dechao Jiao,Aiguo Liu,Kongming Wu. Tumor organoids: applications in cancer modeling and potentials in precision medicine. J Hematol Oncol. 2022; 15, 58.
2. Malia Alexandra Foo, Mingliang You, Lingzhi Wang, Boon‑Cher Goh, et al. Clinical translation of patient-derived tumor organoids- bottlenecks and strategies Preclinical tumor models are an important platform for mechanistic research and testing of new drugs.Biomark Res. 2022 Mar 10;10(1):10. 3. Jarno Drost, Hans Clevers.Organoids in cancer research.Nat Rev Cancer. 2018 Jul;18(7):407-418. 4. Bauer L. LeSavage, Sarah C. Heilshorn, et al. Next-generation cancer organoids. Nat Mater. 2022 Feb;21(2):143-159. 5. Zilong Zhou, Lele Cong, Xianling Cong. Patient-Derived Organoids in Precision Medicine: Drug Screening, Organoid-on-a-Chip and Living Organoid Biobank. Front Oncol. 2021 Dec 30;11:762184. 6. Colin Rae, Francesco Amato, Chiara Braconi. Patient-Derived Organoids as a Model for Cancer Drug Discovery.Int J Mol Sci. 2021 Mar 27;22(7):3483. 7. Georgios Vlachogiannis, Nicola Valeri, et al. Patient-derived organoids model treatment response of metastatic gastrointestinal cancers. Science. 2018 Feb 23;359(6378):920-926.