个人简介
施一公，
1985年保送进入清华大学生物科学与技术系，1989年提前一年毕业，获学士学位；1995年获美国约翰霍普金斯大学医学院分子生物物理博士学位，随后在美国纪念斯隆-凯特琳癌症中心进行博士后研究；1998—2008年历任美国普林斯顿大学分子生物学系助理教授、副教授、教授、Warner-Lambert/Parke-Davis讲席教授。2008年全职回到清华大学工作，曾任清华大学副校长、生命科学与医学研究院院长。2018年至今，担任西湖大学讲席教授、校长。
研究方向
主要运用结构生物学、生物化学和生物物理手段研究细胞凋亡的分子机制、重要膜蛋白以及细胞内生物大分子机器的结构与功能。
代表论文
1.
Rui Bai, Ruixue Wan*, Lin Wang, Kui Xu, Qiangfeng Zhang, Jianlin Lei,
Yigong Shi
* (2021). Structure of the activated human minor spliceosome.
Science,
371(6535): eabg0879.
(
*
co-corresponding authors)
2.
Guanghui Yang, Rui Zhou, Xuefei Guo, Chuangye Yan, Jianlin Lei,
Yigong Shi
(2020).
Structural basis of γ-secretase inhibition and modulation by small molecule drugs.
Cell
, 184(2): 521-533.
3.
Rui Bai
,
Ruixue Wan
*
,
Chuangye Yan
,
Qi Jia
,
Jianlin Lei
,
Yigong Shi
* (2020). Mechanism of spliceosome remodeling by the ATPase/helicase Prp2 and its coactivator Spp2.
Sc
ience
, 371(6525): eabe8863.
(
*
co-corresponding authors)
4.
Ruixue Wan, Rui Bai, Chuangye Yan, Jianlin Lei,
Yigong Shi
(2019). Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of Branching.
Cell
, 177(2): 339-351.
5.
Rui Zhou, Guanghui Yang, Xuefei Guo, Qiang Zhou, Jianlin Lei,
Yigong Shi
(2019). Recognition of the amyloid precursor protein by human γ-secretase.
Science
, 363(6428): eaaw0930.
6.
Xiechao Zhan, Chuangye Yan
*
, Xiaofeng Zhang, Jianlin Lei,
Yigong Shi*
(2018). Structure of a human catalytic step I spliceosome.
Science
, 359(6375): 537-545.
(
*
co-corresponding authors)
7.
Rui Bai, Ruixue Wan, Chuangye Yan, Jianlin Lei,
Yigong Shi
(
2018
).
Structures of the fully assembled
Saccharomyces cerevisiae
spliceosome
before activation
.
Science
,
360(6396):
1423-1429.
8.
Xiaofeng Zhang, Chuangye Yan
*
, Jing Hang, Lorenzo I. Finci, Jianlin Lei,
Yigong Shi*
(2017). An Atomic Structure of the Human Spliceosome.
Cell
, 169(5): 918-929.
(
*
co-corresponding authors)
9.
Chuangye Yan, Jing Hang, Ruixue Wan, Min Huang, Catherine C. L. Wong,
Yigong Shi
(2015). Structure of a yeast spliceosome at 3.6-angstrom resolution.
Science,
349(6253): 1182-1191.
10.
Peilong Lu, Xiao-chen Bai, Dan Ma, Tian Xie, Chuangye Yan, Linfeng Sun, Guanghui Yang, Yanyu Zhao, Rui Zhou, Sjors H. W. Scheres
*
&
Yigong Shi*
(2014). Three-dimensional structure of human
γ
-secretase.
Nature,
512(7513): 166-170.
(
*
co-corresponding authors)
