化学学院 特聘研究员
赵剑楠博士毕业于四川大学，师从冯小明院士，博士研究方向为烯酮亚胺参与的不对称Mannich反应。2015年加入加州大学洛杉矶分校(UCLA) Ohyun Kwon教授课题组开展博士后研究工作，首次实现了可见光催化的交叉[2+2]环加成反应。2018年10月，入职大连理工大学。主要研究兴趣为新型自由基反应开发，光催化连续流反应设计，及手性药物和具有生物活性化合物的合成研究。目前为止，已取得了多项创新性研究成果，在J. Am. Chem. Soc., Angew. Chem. Int. Ed., Org. Lett., Org. Chem. Front.等刊物发表多篇SCI论文。应邀参加于德国林岛举办的第65届诺贝尔奖获得者大会，并获得后续资助。
诚招博后、研究助理、博士、硕士研究生以及交流生
Publications：
[18] Chuyu Xiao,
#
Jing-Ran Shan,
#
Wen-Deng Liu, Xingyuan Gao, Jingwei Dai, Zuwei Wang, Wentao Wang, K. N. Houk,*
Jiannan Zhao*
"Stereoselective Radical Acylfluoroalkylation of Bicyclobutanes via N-Heterocyclic Carbene Catalysis"
Angew. Chem. Int. Ed.
,
2024
, accepted, DOI:10.1002/anie.202416781.
[17] Wen-Deng Liu, Jiyuan Gao, Jia-Nan Mo, Yuqiao Zhou,
*
Jiannan Zhao*
"Cooperative NHC and Photoredox Catalyzed Radical Aminoacylation of Alkenes to Tetrahydropyridazines"
Chem. Eur. J.
2024
,
30
, e202402288. (Invited Paper)
Published as part of Special Collection "Chirality: From Small Molecules to Macromolecules"
[16] Jia-Nan Mo, Shengbin Sun, Huiwei Xu, Hanyu Shu,
Jiannan Zhao*
"
Synthesis of γ‑Oxo-phosphonates via N‑Heterocyclic CarbeneCatalyzed Acylphosphorylation of Alkenes"
Org. Lett.
2024
,
26
, 2197−2201.
Published as part of Virtual Special Issue "Radical Reactions for the Construction and Transformation of Complex Molecules"
[15] Hanyu Shu
#
, Jia-Nan Mo
#
, Wen-Deng Liu,
Jiannan Zhao*
"Synthesis of Pyrroloindolines via N‑Heterocyclic Carbene Catalyzed Dearomative Amidoacylation of Indole Derivatives"
Org. Lett.
2023
,
25
, 8677−5584.
[14] Junqi Su, Aobo Chen, Guofeng Zhang, Ziyu Jiang,
Jiannan Zhao*
"Photocatalytic Phosphine-Mediated Thioesterification of Carboxylic Acids with Disulfides"
Org. Lett.
2023
,
25
, 8033−8037.
[13] Junqi Su, Jia-Nan Mo, Guofeng Zhang, Ziyu Jiang,
Jiannan Zhao*
"A Practical Approach for Oligopeptide Synthesis via Synergistic Photoredox, Cobaloxime and Organophosphorus Triple Catalysis"
Org. Chem. Front.
2023
,
10
, 4895
−
4904.
Highlighted by
Synfacts
2024
,
20
, 105.
[12] Huiwei Xu, Wanyao Zheng, Wen-Deng Liu, Yuqiao Zhou,* Luqing Lin,
Jiannan Zhao*
"Silylacylation of Alkenes through N‑Heterocyclic Carbene Catalysis"
Org. Lett.
2023
,
25
, 5579−5584.
[11] Wencheng Han, Wen-Deng Liu, Junqi Su,
Jiannan Zhao*
"Deoxygenation of Oximes for the Synthesis of Pyrrolines via Hydroimination Cyclization"
Org. Biomol. Chem.
2023
,
21
, 3350−3354.
[10] Huiwei Xu, Jia-Nan Mo, Wen-Deng Liu,
Jiannan Zhao*
"
N
-Heterocyclic Carbene-Catalyzed Remote C(sp
3
)–H Acylation of Amides"
Tetrahedron Lett.
2023
,
121
, 154483.
[9] Wen-Deng Liu
#
, Woojin Lee
#
, Hanyu Shu, Chuyu Xiao, Huiwei Xu, Xiangyang Chen, Kendall N. Houk
*
,
Jiannan Zhao*
"Diastereoselective Radical Aminoacylation of Olefins through N-Heterocyclic Carbene Catalysis"
J. Am. Chem. Soc.
2022
,
144,
22767
−22777.
Highlighted by
Synfacts
2023
,
19
, 183.
[8] Wencheng Han, Junqi Su, Jia-Nan Mo,
Jiannan Zhao*
"Photoredox Catalytic Phosphine-Mediated Deoxygenation of Hydroxylamines Enables the Construction of
N
-Acyliminophosphoranes"
Org. Lett.
2022
,
24
, 6247
−6251.
[7]
Jiannan Zhao
Introducing...
Angew. Chem. Int. Ed.
2022
,
61
,
e202116270.
[6] Junqi Su, Jia-Nan Mo, Xiangyang Chen, Alexander Umanzor, Zheng Zhang, Kendall N. Houk,
Jiannan Zhao*
“Generation of Oxyphosphonium Ions by Photoredox/Cobaloxime Catalysis for Scalable Amide and Peptide Synthesis in Batch and Continuous-Flow”
Angew. Chem. Int. Ed.
,
2022
,
61
, e202112668. (Hot Paper, Cover)
[5]
Jia-Nan Mo, Junqi Su,
Jiannan Zhao*
"
The Asymmetric A
3
(Aldehyde–Alkyne–Amine) Coupling: Highly Enantioselective Access to Propargylamines"
Molecules
2019
,
24
, 1216.
[4]
Jiannan Zhao
, Jonathan L. Brosmer, Qingxuan Tang, Zhongyue Yang, K. N. Houk, Paula L. Diaconescu, Ohyun Kwon*“Intramolecular Crossed [2+2] Photocycloaddition through Visible Light-Induced Energy Transfer”
J. Am. Chem. Soc.
2017
,
139
, 9807−9810.
[3]
Jiannan Zhao
, Bing Fang, Weiwei Luo, Xiaoyu Hao, Xiaohua Liu, Lili Lin, and Xiaoming Feng* “Enantioselective Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Silyl Ketene Imines with Isatin-Derived Ketimines”
Angew. Chem. Int. Ed.
,
2015
,
54
, 241–244.
[2]
Jiannan Zhao
, Xiaohua Liu, Weiwei Luo, Mingsheng Xie, Lili Lin, and Xiaoming Feng* “Asymmetric Synthesis of β-Amino Nitriles through a Sc
III
-Catalyzed Three-Component Mannich Reaction of Silyl Ketene Imines”
Angew. Chem. Int. Ed.,
2013
,
52
, 3473–3477.
[1]
Jiannan Zhao
, Ke Zheng, Yang Yang, Jian Shi, Lili Lin, Xiaohua Liu, Xiaoming Feng*“Asymmetric Mukaiyama Aldol Reaction Catalyzed by C
2
-Symmetric N,N'-Dioxide–Ni(II) Complex”
Synlett
,
2011
, 903–906.
Book Chapters:
Jiannan Zhao
, Shunxi Dong, Xiaoming Feng*, "[4+2]-Cycloadditions (Inverse-Electron-Demand Hetero-Diels-Alder Reaction)" Elsevier, DOI:10.1016/B978-0-32-390644-9.00002-0.
