陈新，博士，副教授，硕士研究生导师。 2016 年 8 月由广东工业大学“青年百人”人才计划引进，广东省物联网重点实验室、广东工业大学智能信息处理研究所成员。长期从事数据分析、组学大数据、大规模生物分子网络调控、肿瘤分子标志物相关研究。近期研究兴趣包括： 1) 单细胞复杂转录调控网络角度下的细胞异质性研究 ; 2) 肿瘤预后相关新型分子标志物的识别 ; 3) 分子标志物相关数据库建设。目前已发表论文 20余 篇，申请发明专利 4 项，主持国家自然科学青年项目 1 项、广东省自然科学基金面上项目 2 项，广州市基础与应用基础研究项目 1 项，并作为主要参与人参加多项国家级及省部级项目。

欢迎对大数据、机器学习、深度学习感兴趣的研究生与本科实习生加入课题组。

[1] 基于单细胞 ceRNA 网络的乳腺癌细胞异质性研究， 国家自然科学基金青年基金，批准号： 62003094 ， 24 万， 2021.01 — 2023.12.

[2] 基于单细胞转录后调控 ceRNA 网络的乳腺癌瘤内细胞异质性研究， 广州市基础与应用基础研究项目（博士青年科技人员类） ，

项目编号：202102020573 ， 5 万 ， 2021.04—2023.03 .

[3] 基于多组学大数据和临床信息优选乳腺癌的预后标记， 广东省自然科学基金面上项目， 批准号： 2019A1515011377 ， 10 万， 2019.10-2022.09.

[4] 基于多来源转录组大数据和临床病理信息识别乳腺癌的预后标志物，广东省自然科学基金面上项目， 批准号： 2018A0303130080 ， 10 万，

2018.05 — 2021.04.

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[1] Liu J ^# , Yu Y ^# , Li M, Wu Y , Chen W , Liu G , Liu L , Lin J , Peng C , Sun W , Wu X *, and Chen X *. PMBC: a manually curated database for prognostic markers of breast cancer, Database (Oxford) , 2024. (Accepted, SCI 4区, IF=5.8 )

[2] Wu X, Gu J, Zou Z, Yu M, Zhang C, Xiao Q, Chen X * , and Li C * . Suppressive Effects of Isofraxidin on Depressive-like Behaviors Induced by Chronic Unpredictable Mild Stress in Mice, Brain Sciences , 2022, 12(10):1376-1387. (SCI 3区, IF=3.3)

[3] Hu L ^# , Chen X ^# , Narwade N ^# , Lim M, Chen Z, Tennakoon C, Guan P, Chan U, Zhao Z, Deng M, Xu X, Sung W*, and Cheung E*. Single-Cell Analysis Reveals Androgen Receptor Regulates the ER-to-Golgi Trafficking Pathway with CREB3L2 to Drive Prostate Cancer Progression, Oncogene , 2021. ( co-first , Nature子刊，SCI 1区, TOP期刊，IF=9.87)

[4] Zhang H, Shao Y, Chen W, and Chen X *. Identifying mitochondrial related genes NDUFA10 and NDUFV2 as prognostic markers for prostate cancer through biclustering, BioMed Research International , 2021, 2021:5512624. (SCI 3区, IF=3.41)

[5] Chen  X ^# , Xu J ^# , Zeng F, Yang C, Sun Wei, Yu T and Li Y*. Inferring Cell Subtypes and LncRNA Function by Cell Specific CeRNA Network in Breast Cancer, Frontiers in Oncology , 2021, 11:656675. (SCI 2 区 , IF=6.24)

[6] Zhang W, Chen X , Sun W, Nie T, Quanquin N, Sun Y ^* . Escherichia Coli Increases its ATP Concentration in Weakly Acidic Environments Principally through the Glycolytic Pathway, Genes (Basel) , 2020, 11(9):991. (SCI 3 区 , IF=3.33)

[7] Chen X , Hu L, Wang Y, Sun W and Yang C ^* . Single Cell Gene Co-Expression Network Reveals FECH/CROT Signature as a Prognostic Marker, Cells , 2019, 8(7). (SCI 2 区 , IF=4.37)

[8] Yang C, Chen X ^* , Liu Y, Zhong W, Xie, S. Efficient Task Offloading and Resource Allocation for Edge Computing-Based Smart Grid Networks, IEEE Access , 2019, 7(7). (SCI 2 区 , IF=4.09)

[9] Mo W, Yang C ^* , Chen X , Lin K, Duan S. Optimal Charging Navigation Strategy Design for Rapid Charging Electric Vehicles, Energies , 2019, 12(6). (SCI 3 区 , IF=2.71)

[10] Verma A, Lam Y, Leung Y, Hu X, Chen X , Cheung E, Tam K. Combined use of arginase and dichloroacetate exhibits anti-proliferative effects in triple negative breast cancer cells, J Pharm Pharmacol , 2019, 71(3):306-315. (SCI 3 区 , IF:2.57)

[11] Yang C, Chen X , Liu Y, Zhong W, Xie S ^* . Efficient Task Offloading and Resource Allocation for Edge Computing-Based Smart Grid Networks, 2019 IEEE International Conference on Communications, ICC 2019. (EI 检索会议 )

[12] Chen X , Miao Z, Divate M, Zhao Z and Cheung E ^* . KM-Express: An integrated online patient survival and gene expression analysis tool for the identification and functional characterization of prognostic markers in breast and prostate cancers, Database (Oxford) , 2018, doi: 10.1093/database/bay069. (SCI 3 区 , IF: 3.98)

[13] Chen X , Yang Z, Yang C, Xie K, Sun W, and Xie S ^* . Sparse Gene Coexpression Network Analysis Reveals EIF3J-AS1 as a Prognostic Marker for Breast Cancer, Complexity , 2018, doi: 10.1155/2018/1656273. (SCI 2 区 , IF: 4.62)

[14] Yan L, Jiang B, Li E, Wang X, Ling Q, Zheng D, Woo J, Chen X , Cheung E, Du X, Li Y, Cheng G, He E, Xu R ^* . Scalable Generation of Mesenchymal Stem Cells from Human Embryonic Stem Cells in 3D, International Journal of Biological Sciences , 2018, 14(10):1196-1210. (SCI 2 区 , IF: 4.86)

[15] Lingadahalli S, Jadhao S, Sung YY, Chen M, Hu L, Chen X , Cheung E ^* . Novel lncRNA LINC00844 Regulates Prostate Cancer Cell Migration and Invasion Through AR Signaling, Mol Cancer Res , 2018, 16(12):1865-1878. (SCI 2 区 , IF: 4.6)

[16] Zhu D ^# , Zhao Z ^# , Cui G, Chang S, Hu L, See Y, Lim M, Guo D, Chen X , Robson P, Luo Y, Cheung E ^* . Single-Cell Transcriptome Analysis Reveals Estrogen Signaling Coordinately Augments One- Carbon, Polyamine, and Purine Synthesis in Breast Cancer, Cell Reports , 2018, 25(8): 2285-2298. (SCI 1 区 , IF: 8.03)

[17] Su Z, Zhang Y, Liao B, Zhong X, Chen X , Wang H, Guo Y, Shan Y, Wang L, Pan G ^* . Antagonism between the transcription factors NANOG and OTX2 specifies rostral or caudal cell fate during neural patterning transition, J Biol Chem , 2018, 293(12):4445-4455. (SCI 2 区 , IF:4.01)

[18] Chen X , Yang C, Xie S, Cheung E ^* . Long non-coding RNA GAS5 and ZFAS1 are prognostic markers involved in translation targeted by miR-940 in prostate cancer, Oncotarget , 2017, 9(1): 1048-1062. (SCI 2 区 , IF: 5.62)

[19] Huang K, Du J, Ma N, Liu J, Wu P, Dong X, Meng M, Wang W, Chen X , Shi X, Chen Q, Yang Z, Chen S, Zhang J, Li Y, Li W, Zheng Y, Cai J, Li P, Sun X, Wang J, Pei D ^* , Pan G ^* . GATA2(-/-) human ESCs undergo attenuated endothelial to hematopoietic transition and thereafter granulocyte commitment, Cell Regeneration, 2015, 4(1):4. (SCI 4 区 , IF: 0.26)

[20] Li Y ^# , Li W ^# , Chen X ^# , Jiang H, Sun J, Chen H, Lv S ^* . Integrated analysis identifies interaction patterns between small molecules and pathways. Biomed Research International , 2014, 2014: 931825. ( co-first , SCI 3 区 , IF:2.19)

[21] Li Y , Huang T , Xiao Y, Ning S, Wang P, Wang Q, Chen X , Chaohan X, Sun D, Li X, Li Y ^* . Prioritising risk pathways of complex human diseases based on functional profiling, European Journal Human Genetics, 2013, 21(6): 666-72. (SCI 2 区 , IF: 4.23)

[22] Chen X ^# , Jiang W ^# , Wang Q, Huang T, Wang P, Li Y, Lv Y, Li X ^* . Systematically characterizing and prioritizing chemosensitivity related gene based on Gene Ontology and protein interaction network, BMC Medical Genomics , 2012, 5(1):43. (SCI 3 区 , IF:3.47)

[23] Lv S ^# , Xu Y ^# , Chen X ^# , Li Y, Li R, Wang Q, Li X ^* , Su B ^* . Prioritizing Cancer Therapeutic Small Molecules by Integrating Multiple OMICS Datasets, OMICS-A Journal of Integrative Biology , 2012, 16(10):552-559. ( co-first , SCI 3 区 , IF:2.73)