Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Department of Neurology, Boston, MA, 02114, USA.
Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Department of Radiology, Charlestown, MA, 02129, USA.
Movement Disorders & Neuromodulation Section, Department for Neurology, Charité - University Medicine Berlin, Berlin, Germany.
Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
City of New York Office of the Chief Medical Examiner, and New York University School of Medicine, New York, NY, 10016, USA.
We present an ultra-high resolution MRI dataset of an
ex vivo
human brain specimen. The brain specimen was donated by a 58-year-old woman who had no history of neurological disease and died of non-neurological causes. After fixation in 10% formalin, the specimen was imaged on a 7 Tesla MRI scanner at 100 µm isotropic resolution using a custom-built 31-channel receive array coil. Single-echo multi-flip Fast Low-Angle SHot (FLASH) data were acquired over 100 hours of scan time (25 hours per flip angle), allowing derivation of synthesized FLASH volumes. This dataset provides an unprecedented view of the three-dimensional neuroanatomy of the human brain. To optimize the utility of this resource, we warped the dataset into standard stereotactic space. We now distribute the dataset in both native space and stereotactic space to the academic community via multiple platforms. We envision that this dataset will have a broad range of investigational, educational, and clinical applications that will advance understanding of human brain anatomy in health and disease.
中文翻译：
我们提出了离体
的超高分辨率 MRI 数据集
人脑标本。大脑标本由一名没有神经系统疾病病史且死于非神经系统原因的 58 岁女性捐赠。在 10% 福尔马林中固定后，使用定制的 31 通道接收阵列线圈在 7 特斯拉 MRI 扫描仪上以 100 µm 各向同性分辨率对标本进行成像。在超过 100 小时的扫描时间（每个翻转角 25 小时）内采集了单回波多次翻转快速低角度射击 (FLASH) 数据，从而可以推导合成的 FLASH 体积。该数据集提供了前所未有的人脑三维神经解剖学视图。为了优化此资源的效用，我们将数据集扭曲到标准立体定向空间中。我们现在通过多个平台将原始空间和立体定向空间中的数据集分发给学术界。
